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Johnson & Johnson
Spring House, PA, United States
25 days ago
Penn Medicine
Radnor, PA, US
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Johnson & Johnson
Spring House, PA, US
Jobs from the Web
Johnson & Johnson
Spring House, Pennsylvania, United States
25 days ago

Description

At Johnson & Johnson, we use technology and the power of teamwork to discover new ways to prevent and overcome the world's the most significant healthcare challenges. Our Corporate, Consumer Health, Medical Devices, and Pharmaceutical teams leverage data, real-world insights, and creative minds to make life-changing healthcare products and medicines. We're disrupting outdated healthcare ecosystems and infusing them with transformative ideas to help people thrive throughout every stage of their lives. With a reach of more than a billion people every day, there's no limit to the impact you can make here. Are you ready to reimagine healthcare?

Here, your career breakthroughs will change the future of health, in all the best ways. And you'll change, too. You'll be inspired, and you'll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us!

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

Global public health and Structural & Protein Sciences departments have a new opportunity for a dedicated, highly motivated Post-Doctoral Fellow with an interest in viral protein structural biology (X-Ray Crystallography/Cryo-EM) to investigate Coronavirus proteins for the fight against SARS-CoV-2 and other future coronavirus epidemics.

GPH is committed to addressing the medical needs of patients in the developing world and resource limited settings and utilizes the resources, capabilities, pharmaceuticals, technologies, access programs, policy initiatives and programs of JRD to positively impact the health and well-being of underserved communities globally. The GPH portfolio includes projects in Coronavirus, Dengue, Tuberculosis, HIV treatment and a Long-Acting formulation platform for HIV, TB, Dengue and Malaria.

The Structural & Protein Sciences (S&PS) department is a global and coordinated team that applies state-of-the-art capabilities to enable small molecule discovery for Janssen R&D by generating high quality proteins to enable assay development, HTS, pharmacological profiling and structural biology (X-ray crystallography, Cryo-EM and NMR). The Protein Science Team collaborates closely with Janssen Therapeutic Areas and functional teams and with external collaborators in academia and industry.

The postdoctoral project will entail design, engineering, and production of various coronavirus structural and non-structural proteins and employ structural biology to investigate the functional implications. You will be working at our state-of the art protein science laboratories in Spring House, PA. The successful candidate will be playing a key role in supporting our efforts in understanding the coronavirus assembly, but also with the potential to work on other Neglected Tropical Diseases.

Responsibilities:
  • Construct design, expression screening, and production of various coronaviral structural and non-structural proteins.
  • Biophysical and biochemical characterization of recombinant proteins.
  • Perform X-ray crystallography and/or Cryo-EM methods to investigate the coronavirus assembly and function.
  • Engaging with GPH and S&PS teams and leverage innovative laboratory technology/infrastructure.
  • Working towards publishing in high-impact journals and to present your research at internal and external meetings.

Qualifications
  • PhD in Biological Sciences, Virology, Biochemistry, Structural Biology or related fields.
  • Experience in construct design and purification of proteins for structure determination using standard techniques and equipment (ex. Westerns, SDS-PAGE, affinity, ion exchange, size exclusion chromatography via AKTA) is required.
  • Experience in protein characterization using techniques (such as analytical gel filtration, mass spectrometry, NanoDSF, and/or dynamic light scattering) is preferred.
  • Experience in membrane protein expression and purification is preferred.
  • Hands-on experience with single particle cryo-EM sample preparation, optimization, data collection and processing is preferred.
  • Experience with target deconvolution and the analysis of complex data sets is preferred.
  • Demonstrate a sense of urgency, be organized and adhere to timelines.
  • Excellent written, oral, and interpersonal communication skills.
  • Excellent problem-solving skills and the competence to adapt to changing priorities.
  • Ability to operate effectively in a team setting within a multicultural environment.
  • Diligent, with strong record-keeping skills

At Johnson & Johnson, we're on a mission to change the trajectory of health for humanity. That starts by creating the world's healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.

Primary Location
United States-Pennsylvania-Spring House-Welsh & McKean Roads
Organization
Janssen Research & Development, LLC (6084)
Job Function
R&D
Requisition ID
2206055974W

Job Information

  • Job ID: 64501910
  • Location:
    Spring House, Pennsylvania, United States
  • Company Name For Job: Johnson & Johnson
  • Position Title: Postdoctoral Fellow, Coronavirus Biochemistry
  • Job Function: Other

Please refer to the company's website or job descriptions to learn more about them.

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